Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL438063 | 0.99 | POLB (0.60) | POLBHTR1DHTR2CMAPTTP53 | |
| SCHEMBL462636 | 0.91 | HTR1D (0.59) | POLBHTR1DHTR2CMAPTTP53 | |
| Hydrochloric Acid SCHEMBL442488 | 0.90 | HTR1D (0.58) | POLBHTR1DHTR2CMAPTTP53 | |
| SCHEMBL10013924 | 0.88 | POLB (0.63) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL439563 | 0.86 | POLB (0.67) | POLBHTR1DHTR2CMAPTTP53 | |
| SCHEMBL404169 | 0.82 | MAPT (0.71) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL406424 | 0.82 | MAPT (0.53) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL342711 | 0.82 | CUL4A (0.60) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL12224815 | 0.82 | HTR1D (0.51) | POLBHTR1DHTR2CMAPTTP53 | |
| SCHEMBL440930 | 0.81 | TSHR (0.46) | POLBHTR1DHTR2CMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | ALCON RESEARCH, LTD (US) | 2012-03-15 | — | — | US | disclosed |
| WO-2012012264-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALLERGY | ALCON RESEARCH, LTD. (US) | 2012-01-26 | — | — | WO | disclosed |
| US-20120015953-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALLERGY | ALCON RESEARCH, LTD. | 2012-01-19 | — | — | US | disclosed |
| US-20120015953-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALLERGY | ALCON RESEARCH, LTD. | 2012-01-19 | — | — | US | disclosed |
| US-20110257137-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2011112731-A2 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-09-15 | — | — | WO | disclosed |
| US-20100120741-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120741-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015953-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALLERGY | HRH4, HRH2, HRH3 | POLB 4619/4885HTR1D 208/4885HTR2C 235/4885 |
| US-20100120741-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | POLB 4705/4885HTR1D 106/4885HTR2C 145/4885 |
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | POLB 4705/4885HTR1D 106/4885HTR2C 145/4885 |
| US-20110257137-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | POLB 4705/4885HTR1D 106/4885HTR2C 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.