SCHEMBL4627481

SCHEMBL4627481

CCOC(=O)c1ccc(F)cc1C(=O)OC(C)(C)C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
CA12 O43570 2/20 0.45
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA7 P43166 2/20 0.45
CA9 Q16790 2/20 0.45
CA14 Q9ULX7 2/20 0.45
HPGD P15428 3/20 0.44
KDM4E B2RXH2 3/20 0.44
HSD17B10 Q99714 3/20 0.44
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
MAPK1 P28482 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
CRHBP P24387 1/20 0.43
CRHR2 Q13324 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
POLB P06746 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
LMNA P02545 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4628672 0.89 TSHR (0.60) TSHRCA12CA1CA2CA7
SCHEMBL4626422 0.86 TSHR (0.54) TSHRKDM4EHSD17B10MAPK1SMN1; SMN2
SCHEMBL4641209 0.85 TSHR (0.50) TSHRCA12CA1CA2CA7
SCHEMBL4627939 0.85 TSHR (0.51) TSHRCA12CA1CA2CA7
SCHEMBL4627555 0.84 TSHR (0.50) TSHRCA12CA1CA2CA7
SCHEMBL6911127 0.82 TSHR (0.49) TSHRCA12CA1CA2CA7
SCHEMBL4628005 0.82 TSHR (0.49) TSHRCA12CA1CA2CA7
SCHEMBL4626516 0.82 TSHR (0.49) TSHRCA12CA1CA2CA7
SCHEMBL4627116 0.81 TSHR (0.48) TSHRCA12CA1CA2CA7
SCHEMBL27812272 0.81 TSHR (0.75) TSHRKDM4EHSD17B10MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1209172-B1 SOLID CATALYST COMPONENT AND CATALYST FOR OLEFIN POLYMERIZATION TOHO TITANIUM CO LTD (JP) 2008-07-02 EP disclosed
US-6770586-B2 Solid catalyst component and catalyst for olefins polymerization TOHO TITANIUM CO., LTD. (JP) 2004-08-03 US disclosed
US-20030130109-A1 Solid catalyst component and catalyst for olefins polymerization TOHO TITANIUM CO., LTD (JP) 2003-07-10 US disclosed
EP-1209172-A1 SOLID CATALYST COMPONENT AND CATALYST FOR OLEFIN POLYMERIZATION Toho Titanium Co., Ltd. (JP) 2002-05-29 EP disclosed