Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389114 | 0.88 | CFTR (0.60) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL2391916 | 0.84 | CFTR (0.59) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL28922445 | 0.77 | CFTR (0.66) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL16155019 | 0.76 | CFTR (0.65) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL12021191 | 0.74 | CFTR (0.62) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL31216058 | 0.74 | CFTR (0.58) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL19535269 | 0.74 | KDM4E (0.56) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL8735628 | 0.74 | KDM4E (0.51) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL24918216 | 0.73 | CFTR (0.60) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL857614 | 0.73 | KDM4E (0.74) | CFTRKDM4EALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871749-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006108591-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | NOVARTIS AG (CH) | 2006-10-19 | — | — | WO | disclosed |