Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | ROS1 | P08922 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | FADS1 | O60427 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460709 | 0.84 | NTRK1 (0.57) | NTRK1JAK2ROS1 | |
| SCHEMBL460710 | 0.84 | NTRK1 (0.57) | NTRK1JAK2ROS1 | |
| SCHEMBL462737 | 0.79 | NTRK1 (0.59) | NTRK1JAK2 | |
| SCHEMBL462170 | 0.75 | NTRK1 (0.55) | NTRK1JAK2 | |
| SCHEMBL460633 | 0.75 | NTRK1 (0.55) | NTRK1JAK2 | |
| SCHEMBL12477947 | 0.72 | NTRK1 (0.45) | NTRK1JAK2ROS1RIPK1 | |
| SCHEMBL12477980 | 0.71 | NTRK1 (0.44) | NTRK1JAK2RIPK1 | |
| SCHEMBL12477982 | 0.71 | NTRK1 (0.44) | NTRK1JAK2RIPK1 | |
| SCHEMBL18863642 | 0.70 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL18863641 | 0.70 | NTRK1 (1.00) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034095-A1 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | claimed |