Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 11/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3559199 | 0.94 | DDR1 (0.36) | TSHRDDR1CA12CA9 | |
| SCHEMBL4628111 | 0.87 | DDR1 (0.36) | DDR1 | |
| SCHEMBL1661288 | 0.85 | DDR1 (0.37) | DDR1CA12CA9 | |
| SCHEMBL4627730 | 0.85 | DDR1 (0.37) | DDR1KDM4EALDH1A1CA12CA9 | |
| SCHEMBL4628707 | 0.84 | DDR1 (0.37) | DDR1CA12CA9 | |
| SCHEMBL4627637 | 0.83 | DDR1 (0.37) | DDR1 | |
| SCHEMBL4627649 | 0.83 | CA12 (0.38) | DDR1CA12CA9 | |
| SCHEMBL2391466 | 0.80 | DDR1 (0.38) | DDR1CA12CA9 | |
| SCHEMBL2390017 | 0.80 | DDR1 (0.38) | DDR1CA12CA9 | |
| SCHEMBL1661310 | 0.80 | AR (0.35) | DDR1KDM4EALDH1A1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871749-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | Novartis AG (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006108591-A1 | 1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS | NOVARTIS AG (CH) | 2006-10-19 | — | — | WO | disclosed |