Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 17/20 | 0.72 |
| ▸ | SCN5A | Q14524 | 16/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629432 | 0.84 | SCN2A (1.00) | SCN2ASCN5A | |
| SCHEMBL4627593 | 0.83 | SCN2A (1.00) | SCN2ASCN5A | |
| SCHEMBL4628968 | 0.80 | SCN2A (1.00) | SCN2ASCN5A | |
| SCHEMBL4628781 | 0.78 | SCN2A (1.00) | SCN2ASCN5ANPC1RAB9AMEN1 | |
| SCHEMBL4628782 | 0.78 | SCN2A (1.00) | SCN2ASCN5ANPC1RAB9AMEN1 | |
| SCHEMBL11160951 | 0.77 | SCN2A (0.47) | SCN2ASCN5A | |
| SCHEMBL10094807 | 0.75 | HDAC1 (0.73) | SCN2ASCN5ANPC1RAB9AHDAC1 | |
| SCHEMBL4629436 | 0.74 | SCN2A (1.00) | SCN2ASCN5ANPC1RAB9A | |
| SCHEMBL4629470 | 0.74 | SCN5A (0.83) | SCN2ASCN5A | |
| SCHEMBL4629427 | 0.72 | SCN5A (0.70) | SCN2ASCN5ANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032556-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | WYETH CORP (US) | 2007-12-19 | — | — | EP | claimed |
| EP-1918272-A1 | Pharmaceutically active compounds and methods of use | Wyeth a Corporation of the State of Delaware (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1032556-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| EP-1032556-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE INC (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1032556-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999020599-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-04-29 | — | — | WO | disclosed |