Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.66 |
| ▸ | HTR1B | P28222 | 9/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.60 |
| ▸ | HTR1A | P08908 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | HTR2B | P41595 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953962 | 0.97 | HTR1D (0.70) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| SCHEMBL684149 | 0.90 | HTR1D (0.71) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| SCHEMBL953214 | 0.89 | HTR1D (0.62) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| Oxymetazoline SCHEMBL4629825 | 0.83 | HTR1D (0.86) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| SCHEMBL953076 | 0.79 | HTR1D (1.00) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| Oxymetazoline SCHEMBL4630526 | 0.79 | HTR1D (0.91) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7969470 | 0.78 | HTR1D (0.97) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| SCHEMBL22953216 | 0.77 | HTR1D (0.78) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| SCHEMBL953638 | 0.77 | HTR1D (0.76) | HTR1DHTR1BTAAR1ADRA2AADRA2B | |
| SCHEMBL7982884 | 0.77 | HTR1D (1.00) | HTR1DHTR1BTAAR1ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |