SCHEMBL4629127

SCHEMBL4629127

CC1(C)CN(C(=O)COC(=O)NC2CCCC2)c2cc(N3C(=O)N(Cc4ccnc(Cl)c4)C(C)(C)C3=O)ccc21

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 19/20 0.45
CHRM1 P11229 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1883175 0.89 IGF1R (0.47) IGF1RCHRM1
SCHEMBL1876987 0.84 IGF1R (0.54) IGF1R
SCHEMBL12636517 0.84 IGF1R (0.51) IGF1R
SCHEMBL1876001 0.83 IGF1R (0.49) IGF1R
SCHEMBL1876890 0.83 IGF1R (0.55) IGF1R
SCHEMBL4149811 0.82 IGF1R (0.46) IGF1R
SCHEMBL1879532 0.82 IGF1R (0.51) IGF1R
SCHEMBL4149813 0.81 IGF1R (0.47) IGF1R
SCHEMBL1876995 0.81 IGF1R (0.44) IGF1R
SCHEMBL1130586 0.80 IGF1R (0.43) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979339-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2008-10-15 EP disclosed
WO-2007083017-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2007-07-26 WO disclosed