Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094740 | 0.92 | ACVR1 (0.53) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL4792360 | 0.92 | ABL1 (0.52) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL4763982 | 0.91 | ABL1 (0.51) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL5094758 | 0.90 | ACVR1 (0.56) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL5096977 | 0.87 | ABL1 (0.54) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL5103305 | 0.86 | ABL1 (0.59) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL5090825 | 0.85 | ABL1 (0.56) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL4763579 | 0.84 | ACVR1 (0.55) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL4629853 | 0.84 | ABL1 (0.55) | ABL1BCRACVR1CDK1CCNB2 | |
| SCHEMBL5142460 | 0.84 | ACVR1 (0.54) | ABL1BCRACVR1CDK1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917258-A2 | PYRIMIDINYL-PYRAZOLE INHIBITORS OF AURORA KINASES | SmithKline Beecham Corporation (US) | 2008-05-07 | — | — | EP | claimed |
| WO-2007024843-A2 | PYRIMIDINYL-PYRAZOLE INHIBITORS OF AURORA KINASES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-01 | — | — | WO | claimed |