Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 12/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953083 | 0.82 | TAAR1 (0.68) | TAAR1HTR1ANISCHMAPK1ADRA1A | |
| SCHEMBL952681 | 0.74 | TAAR1 (1.00) | TAAR1HTR1AADRA2ACYP2D6ADRA2B | |
| SCHEMBL953493 | 0.73 | TAAR1 (1.00) | TAAR1HTR1ANISCHMAPK1ADRA1A | |
| SCHEMBL4629815 | 0.72 | TAAR1 (0.46) | TAAR1HTR1ANISCHADRA1AADRA2A | |
| SCHEMBL26078566 | 0.71 | TAAR1 (0.68) | TAAR1HTR1ANISCHMAPK1ADRA1A | |
| SCHEMBL955372 | 0.71 | TAAR1 (0.80) | TAAR1HTR1AADRA1AADRA2AADRA2B | |
| SCHEMBL954867 | 0.70 | TAAR1 (0.70) | TAAR1HTR1ANISCHMAPK1ADRA1A | |
| Naphazoline SCHEMBL9789833 | 0.70 | TAAR1 (0.70) | TAAR1HTR1ANISCHMAPK1ADRA1A | |
| SCHEMBL4630336 | 0.70 | TAAR1 (0.47) | TAAR1HTR1ANISCHMAPK1ADRA1A | |
| SCHEMBL953494 | 0.69 | TAAR1 (1.00) | TAAR1HTR1ANISCHMAPK1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |