Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 11/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628140 | 0.93 | JAK2 (0.53) | JAK2ACVR1HDAC1HDAC6JAK3 | |
| SCHEMBL4629751 | 0.90 | ACVR1 (0.49) | JAK2ACVR1JAK3FLT3EGFR | |
| SCHEMBL4629170 | 0.89 | ACVR1 (0.53) | JAK2ACVR1HDAC1HDAC6FLT3 | |
| SCHEMBL4628222 | 0.88 | JAK2 (0.54) | JAK2ACVR1HDAC1HDAC6JAK3 | |
| SCHEMBL5097014 | 0.86 | FLT3 (0.49) | JAK2ACVR1JAK3PTK2FLT3 | |
| SCHEMBL5090865 | 0.84 | JAK2 (0.48) | JAK2ACVR1JAK3PTK2FLT3 | |
| SCHEMBL5103276 | 0.84 | JAK2 (0.54) | JAK2ACVR1JAK3FLT3EGFR | |
| SCHEMBL5094850 | 0.81 | JAK2 (0.54) | JAK2ACVR1HDAC1HDAC6JAK3 | |
| SCHEMBL4629829 | 0.80 | JAK2 (0.58) | JAK2ACVR1HDAC1HDAC6FLT3 | |
| SCHEMBL5103304 | 0.80 | KIT (0.57) | JAK2ACVR1HDAC1HDAC6JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | claimed |
| EP-1917258-A2 | PYRIMIDINYL-PYRAZOLE INHIBITORS OF AURORA KINASES | SmithKline Beecham Corporation (US) | 2008-05-07 | — | — | EP | claimed |
| WO-2007024843-A2 | PYRIMIDINYL-PYRAZOLE INHIBITORS OF AURORA KINASES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-01 | — | — | WO | claimed |
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | AURKA, AURKC, PLK1 | JAK2 205/4885ACVR1 1609/4885HDAC1 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.