Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.60 |
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953728 | 0.89 | TAAR1 (0.73) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL954891 | 0.86 | TAAR1 (0.76) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL4630286 | 0.85 | TAAR1 (0.79) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL26078623 | 0.82 | NISCH (0.58) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL26078523 | 0.81 | TAAR1 (0.70) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL952502 | 0.80 | TAAR1 (0.64) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL954681 | 0.80 | TAAR1 (0.73) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL953541 | 0.78 | TAAR1 (0.63) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL4630017 | 0.77 | TAAR1 (0.52) | TAAR1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL953493 | 0.76 | TAAR1 (1.00) | TAAR1NISCHADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |