Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.82 |
| ▸ | HTR1D | P28221 | 6/20 | 0.82 |
| ▸ | HTR1B | P28222 | 5/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26078508 | 0.95 | TAAR1 (0.79) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| SCHEMBL953521 | 0.91 | HTR1D (1.00) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| SCHEMBL955616 | 0.91 | TAAR1 (1.00) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| SCHEMBL21519443 | 0.81 | TAAR1 (0.81) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| SCHEMBL954445 | 0.81 | HTR1D (0.79) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| SCHEMBL8237127 | 0.81 | TAAR1 (0.79) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| SCHEMBL952955 | 0.81 | TAAR1 (0.79) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| SCHEMBL956643 | 0.81 | TAAR1 (0.79) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| SCHEMBL953728 | 0.80 | TAAR1 (0.73) | TAAR1HTR1DHTR1BADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL956502 | 0.79 | TAAR1 (0.77) | TAAR1HTR1DHTR1BADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |