SCHEMBL4630945

SCHEMBL4630945

CC(C)(C)C#Cc1cccc(C(N)=O)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.51
PARP1 P09874 10/20 0.49
TSHR P16473 2/20 0.44
HAO1 Q9UJM8 1/20 0.42
PTGES2 Q9H7Z7 1/20 0.42
MAP3K14 Q99558 2/20 0.41
PARP10 Q53GL7 3/20 0.41
PARP15 Q460N3 2/20 0.41
POLB P06746 1/20 0.39
CYP3A4 P08684 1/20 0.39
MAPT P10636 1/20 0.39
CYP2C19 P33261 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39
PMP22 Q01453 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
TNKS O95271 1/20 0.39
PARP14 Q460N5 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL4631027 0.95 GRM5 (0.48) GRM5PARP1TSHRHAO1PTGES2
SCHEMBL3121665 0.89 GRM5 (0.50) GRM5PARP1TSHRHAO1MAP3K14
SCHEMBL3934628 0.85 HAO1 (0.49) HAO1PTGES2POLBMAPTRECQL
SCHEMBL18946169 0.81 GRM5 (0.55) GRM5PARP1TSHRMAP3K14PARP10
SCHEMBL24505937 0.78 CYP2D6 (0.40) TSHRHAO1PTGES2CYP3A4MAPT
SCHEMBL4953884 0.78 HRH3 (0.49) GRM5HAO1PTGES2MAPTCYP2D6
SCHEMBL16719361 0.77 GRM5 (0.55) GRM5PARP1TSHRPOLBCYP3A4
SCHEMBL3942786 0.77 ACACB (0.53) TSHRPOLBMAPTCYP2C19TDP1
SCHEMBL12478968 0.77 GRM5 (0.55) GRM5PARP1TSHRMAP3K14PARP10
Acetic Acid SCHEMBL4631030 0.75 FFAR1 (0.48) HAO1PTGES2L3MBTL1CYP2D6HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1919875-A2 PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS Astex Therapeutics Limited (GB) 2008-05-14 EP claimed
WO-2006136829-A2 PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS ASTEX THERAPEUTICS LIMITED (GB) 2006-12-28 WO claimed
EP-1919875-A2 PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS Astex Therapeutics Limited (GB) 2008-05-14 EP disclosed
WO-2006136829-A2 PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS ASTEX THERAPEUTICS LIMITED (GB) 2006-12-28 WO disclosed