⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632142 | 1.00 | — | — | |
| SCHEMBL4583048 | 0.78 | — | — | |
| SCHEMBL12712839 | 0.78 | — | — | |
| SCHEMBL12712753 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL10605957 | 0.75 | — | — | |
| SCHEMBL6602028 | 0.75 | — | — | |
| SCHEMBL18636828 | 0.75 | — | — | |
| SCHEMBL23595588 | 0.73 | — | — | |
| Ammonia Solution, Strong SCHEMBL19066600 | 0.73 | — | — | |
| SCHEMBL11243179 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230338317-A1 | FORMULATIONS FOR ADMINISTRATION OF EFLORNITHINE | Orbus Therapeutics, Inc. | 2023-10-26 | — | — | US | disclosed |
| US-20170273926-A1 | COMPOSITIONS AND METHODS FOR USE OF EFLORNITHINE AND DERIVATIVES AND ANALOGS THEREOF TO TREAT CANCERS, INCLUDING GLIOMAS | Orbus Therapeutics, Inc. | 2017-09-28 | — | — | US | disclosed |
| EP-1924588-A1 | CHIRAL PHOSPHORAMIDITES | Studiengesellschaft Kohle mbH (DE) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007031065-A1 | CHIRAL PHOSPHORAMIDITES | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2007-03-22 | — | — | WO | disclosed |
| US-6204297-B1 | POLYOXYALKYLENE GLYCOLS INITIATED WITH DIOLS CONTAINING AT LEAST ON SULFIDE OR DISULFIDE GROUP | RHODIA INC. | 2001-03-20 | — | — | US | disclosed |
| WO-1998023365-A1 | NOVEL NONIONIC GEMINI SURFACTANTS | RHODIA INC. (US) | 1998-06-04 | — | — | WO | disclosed |