SCHEMBL4632293

SCHEMBL4632293

COC(=O)CC1([Si](C)(C)C)C(=O)CCC1=O

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.42
TSHR P16473 3/20 0.33
NPSR1 Q6W5P4 2/20 0.33
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
HSD17B10 Q99714 2/20 0.31
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31
ELANE P08246 1/20 0.31
ALDH1A1 P00352 2/20 0.30
MAPK1 P28482 2/20 0.30
BRD4 O60885 1/20 0.30
HPGD P15428 1/20 0.30
ALOX15 P16050 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9308157 0.72 TP53 (0.43) TP53TSHRNPSR1MEN1MAPT
SCHEMBL7611448 0.68 TSHR (0.44) TP53TSHRMEN1MAPTKMT2A
SCHEMBL24157982 0.64 TP53 (0.40) TP53TSHRMAPTKMT2AHSD17B10
SCHEMBL11285445 0.64 TP53 (0.40) TP53TSHRNPSR1MEN1MAPT
SCHEMBL11640427 0.63 TP53 (0.39) TP53TSHRNPSR1MEN1MAPT
SCHEMBL7174283 0.63 TP53 (0.42) TP53TSHRNPSR1MEN1MAPT
SCHEMBL25540993 0.63 TP53 (0.46) TP53TSHRNPSR1MEN1MAPT
SCHEMBL8321282 0.62 TP53 (0.38) TP53TSHRNPSR1MEN1MAPT
SCHEMBL10351246 0.62 TSHR (0.48) TSHRMEN1MAPTKMT2AHSD17B10
SCHEMBL17233403 0.62 TSHR (0.46) TP53TSHRMEN1KMT2AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1520862-B1 Butadiene polymer, and process for producing conjugated diene polymer AGENCY IND SCIENCE TECHN (JP) 2008-05-28 EP disclosed