Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12577362 | 0.89 | PIK3CD (0.32) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL463255 | 0.77 | PIK3C3 (0.38) | CHEK1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL12577368 | 0.70 | PIK3CD (0.47) | PIK3CDPIM1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2216932 | 0.66 | PIK3CD (0.41) | CHEK1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2212140 | 0.65 | PIK3CD (0.46) | CHEK1PIK3CDPIM1PIK3CAPIK3CB | |
| SCHEMBL459444 | 0.64 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGGSK3B | |
| SCHEMBL1430635 | 0.62 | PIK3CD (0.37) | CHEK1PIK3CDPIM1PIK3CAPIK3CB | |
| SCHEMBL1771925 | 0.62 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1772142 | 0.61 | IDO1 (0.41) | PIM1 | |
| SCHEMBL13578009 | 0.61 | PIM1 (0.36) | PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613781-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |