Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 15/20 | 0.58 |
| ▸ | NEK2 | P51955 | 3/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398692 | 0.93 | PLK1 (0.66) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4413899 | 0.84 | PLK1 (0.62) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4632568 | 0.82 | PLK1 (0.59) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4406541 | 0.82 | PLK1 (0.69) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4397740 | 0.81 | PLK1 (0.55) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL2980041 | 0.79 | PLK1 (0.72) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4404339 | 0.79 | PLK1 (0.72) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4400238 | 0.79 | PLK1 (0.72) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL4404140 | 0.79 | PLK1 (0.61) | PLK1PLK3NEK2PIK3CDNUAK1 | |
| SCHEMBL14029456 | 0.79 | PLK1 (0.65) | PLK1PLK3NEK2PIK3CDNUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |