Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080450 | 0.87 | HTT (0.41) | TSHRHTTSMN1; SMN2AOC3OPRK1 | |
| SCHEMBL30124796 | 0.82 | HRH3 (0.42) | TSHRTRPA1ALDH1A1OPRK1OPRM1 | |
| SCHEMBL6768070 | 0.81 | TAAR1 (0.50) | AOC3 | |
| SCHEMBL3047188 | 0.78 | CYP1A2 (0.52) | ALDH1A1 | |
| SCHEMBL31277039 | 0.78 | TAAR1 (0.52) | TSHRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9045813 | 0.78 | PTGS1 (0.45) | TSHRALDH1A1 | |
| SCHEMBL7717163 | 0.77 | TSHR (0.39) | TSHRTRPA1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL13260233 | 0.76 | CYP1A2 (0.45) | — | |
| SCHEMBL2741643 | 0.76 | CHKA (0.41) | TSHRHTTSMN1; SMN2OPRK1KDM4E | |
| SCHEMBL22047479 | 0.76 | HTT (0.35) | TSHRHTTSMN1; SMN2AOC3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924561-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | Eli Lilly & Company (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007028083-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |