SCHEMBL4632720

SCHEMBL4632720

Cc1cc(Nc2cccc(OCCN3CCC(CC=O)(c4ccccc4)CC3)c2)c2ccccc2n1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.50
HTT P42858 1/20 0.50
NPC1 O15118 1/20 0.42
ADRA2A P08913 2/20 0.41
ADRA2B P18089 1/20 0.41
ADRA2C P18825 1/20 0.41
LMNA P02545 2/20 0.40
UTS2R Q9UKP6 2/20 0.40
DRD2 P14416 1/20 0.40
SLC6A2 P23975 1/20 0.40
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
SLC6A4 P31645 1/20 0.40
TMEM97 Q5BJF2 1/20 0.40
SIGMAR1 Q99720 1/20 0.40
HTR1A P08908 4/20 0.39
HTR1D P28221 4/20 0.39
HTR1B P28222 4/20 0.39
SRC P12931 2/20 0.39
YES1 P07947 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14279627 0.87 TSHR (0.48) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL4828174 0.86 TSHR (0.54) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL14279613 0.85 TSHR (0.52) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL4632717 0.85 TSHR (0.51) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL14279618 0.84 TSHR (0.54) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL4834481 0.84 TSHR (0.52) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL4832281 0.83 TSHR (0.61) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL14288586 0.83 TSHR (0.48) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL4825124 0.82 TSHR (0.54) TSHRHTTNPC1ADRA2AADRA2B
SCHEMBL14279645 0.81 TSHR (0.51) TSHRHTTNPC1ADRA2AADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1603884-A4 PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. ENCYSIVE PHARMACEUTICALS INC (US) 2008-05-28 EP claimed
EP-1603884-A2 PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. ENCYSIVE PHARMACEUTICALS INC. (US) 2005-12-14 EP claimed
WO-2004078114-A2 PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. ENCYSIVE PHARMACEUTICALS INC. (US) 2004-09-16 WO claimed
EP-1603884-A4 PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. ENCYSIVE PHARMACEUTICALS INC (US) 2008-05-28 EP disclosed
EP-1603884-A2 PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. ENCYSIVE PHARMACEUTICALS INC. (US) 2005-12-14 EP disclosed
WO-2004078114-A2 PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. ENCYSIVE PHARMACEUTICALS INC. (US) 2004-09-16 WO disclosed