Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.74 |
| ▸ | PLK3 | Q9H4B4 | 12/20 | 0.74 |
| ▸ | NEK2 | P51955 | 4/20 | 0.62 |
| ▸ | PIM1 | P11309 | 3/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.62 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.62 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.62 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.62 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.62 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.62 |
| ▸ | GRK4 | P32298 | 1/20 | 0.62 |
| ▸ | TIE1 | P35590 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977902 | 0.93 | PLK1 (0.73) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL2988621 | 0.90 | PLK1 (0.75) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL2989081 | 0.89 | PLK1 (0.73) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL2988855 | 0.88 | PLK1 (0.70) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL2978876 | 0.87 | PLK1 (0.69) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL2986893 | 0.87 | PLK1 (0.73) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL2982212 | 0.86 | PLK1 (0.68) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL2989078 | 0.86 | PLK1 (0.74) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL3077938 | 0.85 | PLK1 (0.65) | PLK1PLK3NEK2PIM1PIK3CD | |
| SCHEMBL4632489 | 0.85 | PLK1 (0.66) | PLK1PLK3NEK2PIM1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |