Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4634528 | 0.91 | PTGDR2 (0.45) | RECQLALDH1A1PTGDR2PKMHPGD | |
| SCHEMBL4633816 | 0.91 | RECQL (0.43) | RECQLALDH1A1HPGDNPSR1LMNA | |
| SCHEMBL4634773 | 0.86 | MAPK1 (0.41) | RECQLALDH1A1PTGDR2PKMHPGD | |
| SCHEMBL4633988 | 0.84 | RECQL (0.41) | RECQLALDH1A1PTGDR2PKMHPGD | |
| SCHEMBL4634679 | 0.83 | CCR1 (0.46) | PTGDR2HPGDNPSR1LMNAPOLB | |
| SCHEMBL4634685 | 0.82 | RECQL (0.45) | RECQLALDH1A1PTGDR2HPGDNPSR1 | |
| SCHEMBL4634364 | 0.77 | PTGDR2 (0.43) | RECQLALDH1A1PTGDR2PKMHPGD | |
| SCHEMBL5673235 | 0.76 | RECQL (0.44) | RECQLALDH1A1PTGDR2PKMHPGD | |
| SCHEMBL4634923 | 0.75 | MAPK1 (0.49) | RECQLALDH1A1PTGDR2PKMHPGD | |
| SCHEMBL4633914 | 0.75 | SMN1; SMN2 (0.38) | ALDH1A1HPGDLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928829-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Schering Aktiengesellschaft (DE) | 2008-06-11 | — | — | EP | claimed |
| WO-2006066948-A1 | PIPERIDINE DERIVATIVES AS ANTAGONISTS OF THE CC CHEMOKINE RECEPTOR CCR1 AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-06-29 | — | — | WO | claimed |