Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 18/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325863 | 0.92 | GRM5 (0.58) | GRM5CYP2C19KCNH2 | |
| SCHEMBL4342428 | 0.92 | GRM5 (0.57) | GRM5CYP2C19 | |
| SCHEMBL4635073 | 0.83 | GRM5 (0.42) | GRM5 | |
| SCHEMBL4335449 | 0.81 | GRM5 (0.59) | GRM5CYP2C19 | |
| SCHEMBL4325545 | 0.80 | GRM5 (0.48) | GRM5CYP2C19 | |
| SCHEMBL4343720 | 0.80 | GRM5 (0.48) | GRM5CYP2C19 | |
| SCHEMBL4332896 | 0.80 | GRM5 (0.48) | GRM5CYP2C19 | |
| SCHEMBL4326741 | 0.80 | GRM5 (0.58) | GRM5CYP2C19 | |
| SCHEMBL4635190 | 0.79 | GRM5 (0.50) | GRM5CYP2C19 | |
| SCHEMBL4327921 | 0.79 | GRM5 (0.63) | GRM5CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931635-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-06-18 | — | — | EP | claimed |
| WO-2007023290-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |