Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 13/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.72 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138374 | 1.00 | SLC6A2 (0.72) | SLC6A2SLC6A4C5AR1ALKBH5OPRL1 | |
| SCHEMBL3151314 | 1.00 | SLC6A2 (0.72) | SLC6A2SLC6A4C5AR1ALKBH5OPRL1 | |
| SCHEMBL3137252 | 0.95 | SLC6A2 (0.73) | SLC6A2SLC6A4OPRL1OPRM1OPRK1 | |
| SCHEMBL3150562 | 0.94 | SLC6A2 (0.73) | SLC6A2SLC6A4OPRL1OPRM1OPRK1 | |
| SCHEMBL3138915 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4 | |
| SCHEMBL3150595 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4 | |
| SCHEMBL3141385 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL3133117 | 0.83 | SLC6A2 (0.98) | SLC6A2SLC6A4 | |
| SCHEMBL3142462 | 0.79 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRL1 | |
| SCHEMBL3142477 | 0.79 | SLC6A2 (1.00) | SLC6A2SLC6A4OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934178-A2 | SUBSTITUTED PROPYLAMINE DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007041257-A2 | SUBSTITUTED PROPYLAMINE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2007-04-12 | — | — | WO | disclosed |