Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 15/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324014 | 0.91 | GRM5 (0.46) | GRM5CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL4343490 | 0.80 | GRM5 (0.58) | GRM5MAOB | |
| SCHEMBL4322594 | 0.78 | GRM5 (0.51) | GRM5CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL4329102 | 0.77 | CYP2C19 (0.40) | GRM5CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL13707026 | 0.72 | CYP2C19 (0.43) | GRM5CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL4635284 | 0.70 | GRM5 (0.43) | GRM5CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL4331723 | 0.70 | GRM5 (0.73) | GRM5CYP1A2 | |
| SCHEMBL8283777 | 0.69 | CYP1A2 (0.50) | GRM5CYP2A6CYP2C19CYP1A2CYP11B1 | |
| SCHEMBL4335429 | 0.68 | GRM5 (0.50) | GRM5CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL8243563 | 0.68 | GRM5 (0.62) | GRM5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931635-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007023290-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |