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Sugi Predict / Compounds / SCHEMBL4635373

SCHEMBL4635373

SCHEMBL4635373

CC1(C)CC(=O)c2ccc(C#Cc3cccc(Cl)c3)nc2C1.CC1(C)CC(=O)c2ccc(C#Cc3cccc(F)c3)nc2C1.COc1cccc(C#Cc2ccc3c(n2)CC(C)(C)CC3=O)c1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ GRM5 P41594 16/20 0.50
▸ TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4636362 0.94 GRM5 (0.55) GRM5
SCHEMBL4327965 0.90 GRM5 (0.60) GRM5
SCHEMBL4326741 0.88 GRM5 (0.58) GRM5
SCHEMBL4635755 0.87 GRM5 (0.56) GRM5
SCHEMBL4634739 0.87 GRM5 (0.48) GRM5
SCHEMBL4335449 0.87 GRM5 (0.59) GRM5
SCHEMBL4635190 0.80 GRM5 (0.50) GRM5TP53
SCHEMBL4635572 0.80 GRM5 (0.48) GRM5
SCHEMBL4635802 0.79 GRM5 (0.47) GRM5
SCHEMBL4342428 0.76 GRM5 (0.57) GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931635-A1 TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Merz Pharma GmbH & Co.KGaA (DE) 2008-06-18 — — EP claimed
WO-2007023290-A1 TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS MERZ PHARMA GMBH & CO. KGAA (DE) 2007-03-01 — — WO claimed