SCHEMBL4635395

SCHEMBL4635395

N#C[C@@H]1C[C@H](F)CN1C(=O)CNC1C2CN(c3ccc(C(N)=O)cc3)CC21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 20/20 1.00
DPP8 Q6V1X1 16/20 1.00
DPP7 Q9UHL4 15/20 1.00
DPP9 Q86TI2 14/20 1.00
PREP P48147 11/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4635388 1.00 DPP4 (1.00) DPP4DPP8DPP7DPP9PREP
SCHEMBL4888159 0.91 DPP4 (0.84) DPP4DPP8DPP7DPP9PREP
SCHEMBL4888165 0.91 DPP4 (0.84) DPP4DPP8DPP7DPP9PREP
SCHEMBL4635012 0.90 DPP4 (1.00) DPP4DPP8DPP7DPP9PREP
SCHEMBL4900350 0.90 DPP4 (1.00) DPP4DPP8DPP7DPP9PREP
SCHEMBL4635437 0.89 DPP4 (1.00) DPP4DPP8DPP7DPP9PREP
SCHEMBL4635441 0.89 DPP4 (1.00) DPP4DPP8DPP7DPP9PREP
SCHEMBL4897238 0.88 DPP4 (1.00) DPP4DPP8DPP7DPP9PREP
SCHEMBL4897021 0.88 DPP4 (0.81) DPP4DPP8DPP7DPP9PREP
SCHEMBL4892865 0.87 DPP4 (1.00) DPP4DPP8DPP7DPP9PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080300251-A1 Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors RANBAXY LABORATORIES LIMITED (IN) 2008-12-04 US claimed
US-20080300251-A1 Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors RANBAXY LABORATORIES LIMITED (IN) 2008-12-04 US disclosed
EP-1931633-A2 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS Ranbaxy Laboratories Limited (IN) 2008-06-18 EP disclosed
WO-2007029086-A2 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS RANBAXY LABORATORIES LIMITED (IN) 2007-03-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080300251-A1 Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors DPP4, DPP3, DPP8 DPP4 1/4885DPP8 3/4885DPP7 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.