SCHEMBL4636028

SCHEMBL4636028

N#CC1CC(F)CN1C(=O)CNC1[C@@H]2CN(C(=O)Nc3ccc(Cl)cc3)C[C@@H]12

nearest known ligand 0.65

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 20/20 0.65
DPP7 Q9UHL4 16/20 0.65
DPP8 Q6V1X1 16/20 0.65
PREP P48147 11/20 0.65
DPP9 Q86TI2 15/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4894300 1.00 DPP4 (0.65) DPP4DPP7DPP8PREPDPP9
SCHEMBL4894294 1.00 DPP4 (0.65) DPP4DPP7DPP8PREPDPP9
SCHEMBL4886276 0.91 DPP4 (0.73) DPP4DPP7DPP8PREPDPP9
SCHEMBL4886263 0.91 DPP4 (0.73) DPP4DPP7DPP8PREPDPP9
SCHEMBL4635220 0.87 DPP4 (0.67) DPP4DPP7DPP8PREPDPP9
SCHEMBL4895104 0.87 DPP4 (0.67) DPP4DPP7DPP8PREPDPP9
SCHEMBL4635221 0.87 DPP4 (0.67) DPP4DPP7DPP8PREPDPP9
SCHEMBL4893871 0.84 DPP4 (0.55) DPP4DPP7DPP8PREPDPP9
SCHEMBL4893874 0.84 DPP4 (0.55) DPP4DPP7DPP8PREPDPP9
SCHEMBL4894610 0.81 PREP (0.68) DPP4DPP7DPP8PREPDPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931633-A2 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS Ranbaxy Laboratories Limited (IN) 2008-06-18 EP disclosed
WO-2007029086-A2 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS RANBAXY LABORATORIES LIMITED (IN) 2007-03-15 WO disclosed