Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586979 | 0.93 | GFER (0.82) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL3594355 | 0.92 | NPSR1 (0.61) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL4637251 | 0.90 | GFER (0.62) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL3597411 | 0.84 | GFER (0.79) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL13436127 | 0.84 | GFER (1.00) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL3595926 | 0.83 | NPSR1 (0.57) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL3588697 | 0.83 | GFER (0.76) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL13436130 | 0.83 | NPSR1 (0.76) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL4774958 | 0.83 | GFER (0.61) | GFERNPSR1MAPTALDH1A1KDM4E | |
| SCHEMBL4780336 | 0.83 | GFER (0.61) | GFERNPSR1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937663-A1 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | Inpharmatica Limited (GB) | 2008-07-02 | — | — | EP | claimed |
| WO-2007036730-A9 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | INPHARMATICA LTD (GB) | 2008-06-19 | — | — | WO | claimed |
| WO-2007036730-A1 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | claimed |