Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 17/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908425 | 0.84 | SLC6A2 (0.73) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| Hydrochloric Acid SCHEMBL2901958 | 0.83 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL5668647 | 0.81 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL2903388 | 0.80 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL2904818 | 0.79 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| Hydrochloric Acid SCHEMBL2904809 | 0.79 | SLC6A2 (0.65) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| Hydrochloric Acid SCHEMBL2901659 | 0.78 | SLC6A2 (0.67) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL2904963 | 0.76 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| Hydrochloric Acid SCHEMBL2904611 | 0.75 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL8284213 | 0.74 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729754-B1 | SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF HOT FLASHES | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |