Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.67 |
| ▸ | PDE4A | P27815 | 13/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4637134 | 0.99 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL4638165 | 0.95 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DIRAK4 | |
| SCHEMBL4637176 | 0.94 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4637277 | 0.91 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL4637927 | 0.85 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DIRAK4 | |
| SCHEMBL4637250 | 0.84 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7278844 | 0.84 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7277081 | 0.84 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7289537 | 0.84 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7278849 | 0.84 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |