Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.90 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.90 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.90 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.90 |
| ▸ | TNF | P01375 | 13/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637168 | 0.95 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4638557 | 0.94 | PDE4A (0.92) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637166 | 0.92 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637192 | 0.92 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637162 | 0.87 | PDE4B (0.85) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637285 | 0.87 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637229 | 0.86 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL5905773 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637242 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6691621 | 0.83 | TNF (1.00) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |