Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.41 |
| ▸ | STK3 | Q13188 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550343 | 1.00 | IDO1 (0.45) | IDO1TDO2ALKKDRFLT3 | |
| SCHEMBL7197592 | 0.80 | TDP1 (0.47) | IDO1TDO2ALKKDRFLT3 | |
| SCHEMBL6320390 | 0.79 | GALR3 (0.41) | IDO1TDO2ALKKDRFLT3 | |
| SCHEMBL2342762 | 0.79 | KDR (0.65) | ALKKDRFLT3FGFR1RET | |
| SCHEMBL2111143 | 0.72 | FLT3 (0.73) | ALKKDRFLT3FGFR1RET | |
| SCHEMBL4464503 | 0.72 | FLT3 (0.73) | ALKKDRFLT3FGFR1RET | |
| SCHEMBL4638132 | 0.71 | TDP1 (0.48) | IDO1TDO2ALKKDRFLT3 | |
| SCHEMBL20338612 | 0.70 | FGFR1 (0.61) | IDO1TDO2ALKKDRFLT3 | |
| SCHEMBL20338610 | 0.70 | FGFR1 (0.61) | IDO1TDO2ALKKDRFLT3 | |
| SCHEMBL2115541 | 0.69 | IDO1 (0.46) | IDO1TDO2ALKKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1536783-B1 | SOLID FORMULATIONS COMPRISING AN INDOLINONE COMPOUND | PFIZER ITALIA SRL (IT) | 2008-08-06 | — | — | EP | disclosed |