Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636187 | 0.92 | NR1H4 (0.62) | NR1H4KMT2AATMELANE | |
| SCHEMBL3904116 | 0.91 | NR1H4 (0.47) | NR1H4ELANE | |
| SCHEMBL6250345 | 0.91 | NR1H4 (0.52) | NR1H4KMT2AATMELANE | |
| SCHEMBL6205772 | 0.91 | NR1H4 (0.46) | NR1H4ELANE | |
| SCHEMBL3831828 | 0.90 | NR1H4 (0.56) | NR1H4KMT2AATMELANE | |
| SCHEMBL4783638 | 0.90 | NR1H4 (0.56) | NR1H4KMT2AATMELANE | |
| SCHEMBL6447798 | 0.90 | NR1H4 (0.56) | NR1H4KMT2AATMELANE | |
| SCHEMBL4596921 | 0.89 | NR1H4 (0.50) | NR1H4KMT2AATMELANE | |
| SCHEMBL4851757 | 0.89 | NR1H4 (0.48) | NR1H4KMT2AELANE | |
| SCHEMBL6206446 | 0.89 | NR1H4 (0.55) | NR1H4KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896409-A1 | NOVEL 2-AZETIDINONE DERIVATIVES AS CHOLESTEROL ABSORPTION INHIBITORS USEFUL FOR THE TREATMENT OF HYPERLIPIDAEMIC CONDITIONS | AstraZeneca AB (SE) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006137795-A1 | NOVEL 2-AZETIDINONE DERIVATIVES AS CHOLESTEROL ABSORPTION INHIBITORS USEFUL FOR THE TREATMENT OF HYPERLIPIDAEMIC CONDITIONS | ASTRAZENECA AB (SE) | 2006-12-28 | — | — | WO | disclosed |
| EP-1699759-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061452-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |