SCHEMBL4640903

SCHEMBL4640903

COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@H](OC)[C@H](O)[C@H]3O)ccc2Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 20/20 1.00
SLC5A1 P13866 13/20 0.84
ADRA2A P08913 1/20 0.68
SLC5A11 Q8WWX8 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4640891 1.00 SLC5A2 (1.00) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL30232032 0.92 SLC5A2 (1.00) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL18857855 0.92 SLC5A2 (1.00) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL1551970 0.92 SLC5A2 (1.00) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL14065538 0.91 SLC5A2 (0.83) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL4640121 0.91 SLC5A2 (0.83) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL19620408 0.91 SLC5A2 (0.83) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL14065546 0.91 SLC5A2 (0.83) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL14065549 0.91 SLC5A2 (0.83) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL14065548 0.90 SLC5A2 (0.82) SLC5A2SLC5A1ADRA2ASLC5A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7419959-B2 D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) 2008-09-02 US disclosed
US-7419959-B2 D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) 2008-09-02 US disclosed
US-7419959-B2 D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) 2008-09-02 US disclosed
EP-1797107-B1 D-PYRANOSYL-SUBSTITUTED PHENYLS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM INT (DE) 2008-08-06 EP disclosed
US-20060074031-A1 D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060074031-A1 D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885ADRA2A 769/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.