Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 4/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | CLK3 | P49761 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45468 | 1.00 | CLK1 (0.48) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL45467 | 1.00 | CLK1 (0.48) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL4641203 | 0.99 | CLK1 (0.47) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL4641199 | 0.99 | CLK1 (0.47) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL4955057 | 0.99 | CLK1 (0.47) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL4148685 | 0.91 | CLK1 (0.53) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL2993704 | 0.91 | CLK1 (0.53) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL2993698 | 0.91 | CLK1 (0.53) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL3393661 | 0.90 | CLK1 (0.52) | CLK1DYRK1ADYRK2DYRK1BPIK3CD | |
| SCHEMBL3393650 | 0.90 | CLK1 (0.52) | CLK1DYRK1ADYRK2DYRK1BPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888557-A2 | (5Z)-5-(6-QUINOXALINYLMETHYLIDENE)-2-Ý(2,4,6-TRICHLOROPHENYL)AMINO¨-1,3-THIAZOL-4(5H)-ONE | Smithkline Beecham Corporation (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006133381-A2 | (5Z)-5-(6-QUINOXALINYLMETHYLIDENE)-2-[(2,4,6-TRICHLOROPHENYL)AMINO]-1,3-THIAZOL-4(5H)-ONE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |