Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 4/20 | 0.52 |
| ▸ | ELANE | P08246 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CTSV | O60911 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | CMA1 | P23946 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.52 |
| ▸ | LONP1 | P36776 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.44 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.44 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.44 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.44 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.44 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.44 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013602 | 1.00 | ABCG2 (0.54) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL2410890 | 1.00 | ABCG2 (0.54) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL3213475 | 1.00 | ABCG2 (0.54) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL1013600 | 1.00 | ABCG2 (0.54) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL2408343 | 1.00 | ABCG2 (0.54) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL464151 | 0.99 | ABCG2 (0.53) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL12011280 | 0.92 | ABCG2 (0.54) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL12331437 | 0.92 | ABCG2 (0.54) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL13092003 | 0.92 | ABCG2 (0.54) | ABCG2CTSBELANECTSLCTSV | |
| SCHEMBL12404543 | 0.91 | ABCG2 (0.53) | ABCG2CTSBELANECTSLCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140294763-A1 | PEPTIDOMIMETIC PROTEASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-10-02 | — | — | US | disclosed |
| US-8529882-B2 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-09-10 | — | — | US | disclosed |
| US-20120282219-A1 | PEPTIDOMIMETIC PROTEASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-08 | — | — | US | disclosed |
| US-8252923-B2 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252923-B2 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-08-28 | — | — | US | disclosed |
| US-20120064034-A1 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-15 | — | — | US | disclosed |
| US-20100137583-A1 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2010-06-03 | — | — | US | disclosed |
| US-20100137583-A1 | Peptidomimetic protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140294763-A1 | PEPTIDOMIMETIC PROTEASE INHIBITORS | CTSC, PREP, PEPD | ABCG2 2283/4885CTSB 39/4885ELANE 600/4885 |
| US-20100137583-A1 | Peptidomimetic protease inhibitors | CTSC, PREP, PEPD | ABCG2 2283/4885CTSB 39/4885ELANE 600/4885 |
| US-20120064034-A1 | Peptidomimetic protease inhibitors | CTSC, PREP, PEPD | ABCG2 2283/4885CTSB 39/4885ELANE 600/4885 |
| US-20120282219-A1 | PEPTIDOMIMETIC PROTEASE INHIBITORS | CTSC, PEPD, PREP | ABCG2 1917/4885CTSB 21/4885ELANE 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.