Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377150 | 0.92 | HRH3 (0.48) | HRH3HRH1CCR3KMT2AMEN1 | |
| SCHEMBL3377928 | 0.90 | HRH3 (0.49) | HRH3HRH1CCR3KMT2AMEN1 | |
| SCHEMBL3378180 | 0.90 | HRH3 (0.51) | HRH3HRH1CCR3KMT2AMEN1 | |
| SCHEMBL3380049 | 0.89 | HRH3 (0.49) | HRH3CCR1HRH1CCR3KMT2A | |
| SCHEMBL3380634 | 0.88 | HRH3 (0.49) | HRH3HRH1CCR3KMT2AMEN1 | |
| SCHEMBL3377774 | 0.87 | HRH3 (0.49) | HRH3HRH1CCR3MAPTALDH1A1 | |
| SCHEMBL3378477 | 0.86 | HRH3 (0.54) | HRH3HRH1CCR3SMN1; SMN2 | |
| SCHEMBL3380104 | 0.86 | HRH3 (0.47) | HRH3TDP1HRH1CCR3KMT2A | |
| SCHEMBL3379929 | 0.85 | HRH3 (0.49) | HRH3ALDH1A1SMN1; SMN2MLNR | |
| SCHEMBL3380421 | 0.84 | HRH3 (0.53) | HRH3HRH1CCR3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | claimed |