SCHEMBL4645837

SCHEMBL4645837

CCCc1ccc(Cl)c2cc(Cl)ccc12

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.42
IDO1 P14902 3/20 0.38
HPGD P15428 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
MAPK1 P28482 1/20 0.37
CYP2C19 P33261 1/20 0.37
TP53 P04637 1/20 0.37
PYCR1 P32322 1/20 0.36
SIRT1 Q96EB6 1/20 0.35
FLT1 P17948 1/20 0.35
FLT4 P35916 1/20 0.35
KDR P35968 1/20 0.35
GAA P10253 1/20 0.35
AHR P35869 1/20 0.35
HTR2A P28223 1/20 0.34
SLC6A4 P31645 1/20 0.34
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10742677 0.81 IDO1 (0.38) IDO1CYP1A2CYP3A4CYP2C9MAPK1
SCHEMBL7224195 0.78 FLT1 (0.46) KCNH2IDO1HPGDCYP1A2CYP3A4
SCHEMBL426435 0.78 IDO1 (0.56) IDO1HPGDCYP1A2CYP3A4CYP2C9
Ammonia Solution, Strong SCHEMBL14718591 0.76 FLT1 (0.45) KCNH2IDO1HPGDCYP1A2CYP3A4
Hydrochloric Acid SCHEMBL7988970 0.76 IDO1 (0.54) IDO1HPGDCYP1A2CYP3A4CYP2C9
SCHEMBL29780384 0.75 TP53 (0.55) CYP1A2CYP3A4MAPK1TP53AHR
SCHEMBL5863631 0.75 TP53 (0.55) CYP1A2CYP3A4MAPK1TP53AHR
SCHEMBL8337975 0.72 CYP3A4 (0.40) KCNH2IDO1HPGDCYP1A2CYP3A4
SCHEMBL19278265 0.72 FLT1 (0.45) KCNH2IDO1HPGDCYP1A2CYP3A4
SCHEMBL7068139 0.71 TP53 (0.39) IDO1CYP1A2CYP3A4CYP2C9MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118139910-A Linear block copolymers and curable thermosetting compositions comprising the same 高新特殊工程塑料全球技术有限公司 2024-06-04 CN disclosed
CN-105431472-B Flame-retardant polycarbonate-siloxane copolymers with silicone-based core-shell modifiers 沙特基础全球技术有限公司 2017-08-25 CN disclosed
CN-101356235-B Polycarbonate compositions and articles formed therefrom, with matte surfaces and high light transmissions SABIC INNOVATIVE PLASTICS IP 2012-07-18 CN disclosed
CN-101511937-B Flame retardant and chemical resistant thermoplastic polycarbonate compositions SABIC INNOVATIVE PLASTICS IP 2012-07-18 CN disclosed
CN-101490156-B Flame retardant and scratch resistant thermoplastic polycarbonate compositions SABIC INNOVATIVE PLASTICS IP 2012-06-27 CN disclosed
CN-101360775-B High glass transition temperature copolycarbonates, methods of manufacture, and uses thereof GEN ELECTRIC 2012-06-27 CN disclosed
CN-101473246-B Infrared transmissive thermoplastic composition, and articles formed therefrom SABIC INNOVATIVE PLASTICS IP 2012-06-20 CN disclosed
CN-101484531-B Flame retardant and scratch resistant thermoplastic polycarbonate compositions SABIC INNOVATIVE PLASTICS IP 2012-05-23 CN disclosed
CN-101553525-B Infrared transmissive thermoplastic composition SABIC INNOVATIVE PLASTICS IP 2012-05-23 CN disclosed
CN-102245690-A Flame retardant thermoplastic polycarbonate compositions SABIC INNOVATIVE PLASTICS IP 2011-11-16 CN disclosed
CN-101356235-A Polycarbonate compositions and articles formed therefrom, with matte surfaces and high light transmissions GEN ELECTRIC (US) 2009-01-28 CN disclosed
CN-101356212-A Copolycarbonate-polyesters, process for their preparation and their use GEN ELECTRIC (US) 2009-01-28 CN disclosed
EP-1957561-A1 HIGH GLASS TRANSITION TEMPERATURE COPOLYCARBONATES, METHODS OF MANUFACTURE, AND USES THEREOF General Electric Company, (a New York Corporation) (US) 2008-08-20 EP disclosed
CN-100406519-C Antistatic flame retardant resin composition and methods for manufacture thereof GEN ELECTRIC (US) 2008-07-30 CN disclosed
CN-101223240-A Thermoplastic polycarbonate compositions, methods of manufacture, and methods of use thereof GEN ELECTRIC (US) 2008-07-16 CN disclosed
CN-101189293-A Thermoplastic polycarbonate compositions, methods of manufacture, and methods of use thereof GEN ELECTRIC (US) 2008-05-28 CN disclosed
CN-101010383-A Thermoplastic polycarbonate compositions, methods of manufacture, and method of use thereof GEN ELECTRIC (US) 2007-08-01 CN disclosed
WO-2007064670-A1 HIGH GLASS TRANSITION TEMPERATURE COPOLYCARBONATES, METHODS OF MANUFACTURE, AND USES THEREOF GENERAL ELECTRIC COMPANY (US) 2007-06-07 WO disclosed
CN-1681885-A Antistatic flame-retardant resin composition and method for producing same GEN ELECTRIC (US) 2005-10-12 CN disclosed
EP-0736567-A2 Flame retardant molding thermoplastics GENERAL ELECTRIC COMPANY (US) 1996-10-09 EP disclosed