Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953379 | 0.98 | PTGDR2 (0.46) | PTGDR2HPGDSMN1; SMN2NPSR1CYSLTR2 | |
| SCHEMBL2771758 | 0.95 | PTGDR2 (0.48) | PTGDR2HPGDSMN1; SMN2NPSR1HTT | |
| SCHEMBL3224950 | 0.90 | HPGD (0.55) | PTGDR2HPGDSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL28657454 | 0.89 | CYSLTR2 (0.40) | PTGDR2HPGDSMN1; SMN2NPSR1CYSLTR2 | |
| SCHEMBL7082046 | 0.88 | PTGDR2 (0.57) | PTGDR2HPGDSMN1; SMN2NPSR1CYSLTR2 | |
| SCHEMBL13581076 | 0.88 | PTGDR2 (0.57) | PTGDR2HPGDSMN1; SMN2NPSR1CYSLTR2 | |
| SCHEMBL10482310 | 0.88 | PTGDR2 (0.57) | PTGDR2HPGDSMN1; SMN2NPSR1CYSLTR2 | |
| SCHEMBL4151896 | 0.88 | PTGDR2 (0.57) | PTGDR2HPGDSMN1; SMN2NPSR1CYSLTR2 | |
| SCHEMBL4134477 | 0.88 | PTGDR2 (0.57) | PTGDR2HPGDSMN1; SMN2NPSR1CYSLTR2 | |
| SCHEMBL12293415 | 0.84 | PTGDR2 (0.60) | PTGDR2HPGDSMN1; SMN2NPSR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885694-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |