Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | CLPP | Q16740 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130714 | 0.89 | GRM5 (0.54) | GRM5CLPPATML3MBTL1MEN1 | |
| SCHEMBL3130726 | 0.89 | GRM5 (0.54) | GRM5CLPPATML3MBTL1MEN1 | |
| SCHEMBL3142456 | 0.89 | GRM5 (0.54) | GRM5CLPPATML3MBTL1MEN1 | |
| SCHEMBL3142468 | 0.89 | GRM5 (0.54) | GRM5CLPPATML3MBTL1MEN1 | |
| SCHEMBL3127414 | 0.87 | GRM5 (0.56) | GRM5CLPPATML3MBTL1MEN1 | |
| SCHEMBL3141641 | 0.87 | GRM5 (0.56) | CCR5GRM5CLPPATML3MBTL1 | |
| SCHEMBL3127426 | 0.87 | GRM5 (0.56) | GRM5CLPPATML3MBTL1MEN1 | |
| SCHEMBL3141649 | 0.87 | GRM5 (0.56) | CCR5GRM5CLPPATML3MBTL1 | |
| SCHEMBL3127437 | 0.87 | GRM5 (0.56) | GRM5CLPPATML3MBTL1MEN1 | |
| SCHEMBL3131747 | 0.87 | GRM5 (0.56) | GRM5CLPPATML3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896464-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2008-03-12 | — | — | EP | claimed |
| WO-2006129199-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2006-12-07 | — | — | WO | claimed |