SCHEMBL4647259

SCHEMBL4647259

COC(=O)[C@H](Cc1ccc(OCCNc2ccccc2Cl)cc1)Nc1ccccc1C(=O)c1ccccc1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.66
PPARA Q07869 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4647266 1.00 PPARG (0.66) PPARGPPARA
SCHEMBL4643428 0.97 PPARG (0.65) PPARGPPARA
SCHEMBL4643419 0.97 PPARG (0.65) PPARGPPARA
SCHEMBL4648235 0.93 PPARG (0.67) PPARGPPARA
SCHEMBL4643348 0.91 PPARG (0.67) PPARGPPARA
SCHEMBL4646020 0.91 PPARG (0.66) PPARGPPARA
SCHEMBL4647456 0.91 PPARG (0.66) PPARGPPARA
SCHEMBL4646004 0.91 PPARG (0.66) PPARGPPARA
SCHEMBL4644288 0.90 PPARG (0.68) PPARGPPARA
SCHEMBL4644281 0.90 PPARG (0.68) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1778624-B1 TYROSINE DERIVATIVES AS PPAR-GAMMA-MODULATORS SALVAT LAB SA (ES) 2008-08-20 EP disclosed