Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 12/20 | 0.78 |
| ▸ | TSHR | P16473 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647285 | 0.88 | GAA (0.60) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL4647903 | 0.87 | GAA (0.76) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL6408711 | 0.87 | GAA (0.76) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL4647258 | 0.85 | TSHR (0.98) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL4647779 | 0.84 | TSHR (1.00) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL4649301 | 0.83 | GAA (0.70) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL4647287 | 0.83 | GAA (0.84) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL4646686 | 0.82 | GAA (0.55) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL4649112 | 0.82 | GAA (0.78) | GAATSHRMEN1ALDH1A1PKM | |
| SCHEMBL4647999 | 0.79 | GAA (0.61) | GAATSHRMEN1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675834-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1675834-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005037799-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-04-28 | — | — | WO | claimed |
| WO-2006031273-A2 | CELLULAR PHENOTYPE | CYTOKINETICS, INC. (US) | 2006-03-23 | — | — | WO | disclosed |