Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 12/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386055 | 0.91 | KDM4E (0.52) | MEN1KMT2ANPC1RAB9AHIF1A | |
| SCHEMBL2384674 | 0.91 | EGFR (0.62) | MEN1KMT2ANPC1RAB9AHIF1A | |
| SCHEMBL2384134 | 0.89 | KMT2A (0.70) | MEN1KMT2ANPC1RAB9AHIF1A | |
| SCHEMBL2399702 | 0.87 | MEN1 (0.77) | MEN1KMT2ANPC1RAB9AHIF1A | |
| SCHEMBL12254566 | 0.82 | KDM4E (0.52) | MEN1KMT2ANPC1RAB9AHIF1A | |
| SCHEMBL2382180 | 0.79 | KDM4E (0.69) | MEN1KMT2AKDM4ETSHREGLN1 | |
| SCHEMBL2386048 | 0.78 | HIF1A (0.62) | MEN1KMT2ANPC1RAB9AHIF1A | |
| SCHEMBL12254380 | 0.78 | KMT2A (0.73) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL15859729 | 0.77 | EGLN1 (0.69) | MEN1KMT2ANPC1RAB9AHIF1A | |
| SCHEMBL2395649 | 0.77 | KMT2A (0.71) | MEN1KMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amgen, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070359-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2007-06-21 | — | — | WO | disclosed |