Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 18/20 | 0.58 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955072 | 0.90 | CXCR2 (0.47) | CXCR2CXCR1CYP2C9 | |
| SCHEMBL18953514 | 0.88 | CXCR2 (0.46) | CXCR2CXCR1CYP2C9KMT2A | |
| SCHEMBL18953471 | 0.88 | CXCR2 (0.59) | CXCR2CXCR1 | |
| SCHEMBL18953469 | 0.88 | CXCR2 (0.59) | CXCR2CXCR1CYP2C9 | |
| SCHEMBL18953618 | 0.88 | CXCR2 (0.59) | CXCR2CXCR1 | |
| SCHEMBL18953362 | 0.86 | CXCR2 (0.43) | CXCR2CXCR1MEN1KMT2A | |
| SCHEMBL18953337 | 0.85 | CXCR2 (0.44) | CXCR2CXCR1CYP2C9KMT2A | |
| SCHEMBL18953524 | 0.85 | CXCR2 (0.44) | CXCR2CXCR1CYP2C9KMT2A | |
| SCHEMBL18953385 | 0.85 | CXCR2 (0.61) | CXCR2CXCR1KMT2A | |
| SCHEMBL18953566 | 0.85 | CXCR2 (0.61) | CXCR2CXCR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631559-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1631559-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005000231-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | claimed |
| EP-1631559-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1631559-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2005000231-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |