Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.78 |
| ▸ | BRAF | P15056 | 14/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648172 | 0.93 | MAPK14 (0.83) | MAPK14BRAFKCNH2PLK4ACOX3 | |
| SCHEMBL2240803 | 0.92 | MAPK14 (0.66) | MAPK14BRAFKCNH2PLK4ACOX3 | |
| SCHEMBL4647894 | 0.92 | MAPK14 (0.72) | MAPK14BRAFPLK4ACOX3MAP3K7 | |
| SCHEMBL400258 | 0.90 | BRAF (0.70) | MAPK14BRAFKCNH2PLK4ACOX3 | |
| SCHEMBL29844334 | 0.88 | MAPK14 (1.00) | MAPK14BRAFKCNH2PLK4ACOX3 | |
| SCHEMBL16749182 | 0.88 | MAPK14 (1.00) | MAPK14BRAFKCNH2PLK4ACOX3 | |
| SCHEMBL4649095 | 0.87 | MAPK14 (0.87) | MAPK14BRAFKCNH2PLK4ACOX3 | |
| SCHEMBL31265636 | 0.87 | MAPK14 (0.86) | MAPK14BRAFPLK4ACOX3MAP3K7 | |
| SCHEMBL2925287 | 0.87 | MAPK14 (0.59) | MAPK14BRAFKCNH2PLK4ACOX3 | |
| SCHEMBL1410447 | 0.86 | MAPK14 (0.69) | MAPK14BRAFKCNH2PLK4ACOX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960394-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Bayer HealthCare AG (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007059202-A2 | PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE AG (DE) | 2007-05-24 | — | — | WO | disclosed |