SCHEMBL4649772

SCHEMBL4649772

CC(=O)c1ccc(Cl)cc1OCC(=O)Nc1ccccc1C(=O)O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM4 Q8TD43 2/20 0.66
POLB P06746 2/20 0.61
G6PD P11413 1/20 0.61
MAPT P10636 4/20 0.59
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
KDM4E B2RXH2 2/20 0.59
ALDH1A1 P00352 1/20 0.59
HCAR2 Q8TDS4 3/20 0.58
CASP3 P42574 1/20 0.57
SENP8 Q96LD8 1/20 0.57
SENP7 Q9BQF6 1/20 0.57
SENP6 Q9GZR1 1/20 0.57
NPC1 O15118 2/20 0.56
RAB9A P51151 2/20 0.56
TP53 P04637 1/20 0.56
CTDSP1 Q9GZU7 1/20 0.55
NOD2 Q9HC29 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.54
GAA P10253 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4650386 0.91 POLB (0.64) TRPM4POLBG6PDMAPTMEN1
SCHEMBL4910731 0.87 TRPM4 (0.64) TRPM4POLBG6PDMAPTMEN1
SCHEMBL4649755 0.87 HCAR2 (0.59) TRPM4POLBMAPTMEN1KMT2A
SCHEMBL4649662 0.86 HCAR2 (0.72) TRPM4POLBMAPTMEN1KMT2A
SCHEMBL4650428 0.86 HCAR2 (0.58) TRPM4POLBG6PDMAPTMEN1
SCHEMBL28777054 0.85 MEN1 (0.58) TRPM4MAPTMEN1KMT2AALDH1A1
SCHEMBL4650500 0.85 HCAR2 (0.57) TRPM4POLBG6PDMEN1KMT2A
SCHEMBL4908222 0.85 MAPT (0.71) TRPM4POLBG6PDMAPTMEN1
SCHEMBL4293544 0.84 MEN1 (0.79) TRPM4POLBG6PDMAPTMEN1
SCHEMBL4650465 0.84 HCAR2 (0.56) TRPM4POLBG6PDMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101336236-A Anthranilic acid derivatives useful in treating infection with hepatitis c virus WYETH CORP (US) 2008-12-31 CN claimed
EP-1966181-A2 ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS Wyeth (US) 2008-09-10 EP claimed
WO-2008051244-A2 ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS WYETH (US) 2008-05-02 WO claimed
EP-1966181-A2 ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS Wyeth (US) 2008-09-10 EP disclosed
WO-2008051244-A2 ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS WYETH (US) 2008-05-02 WO disclosed