Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26132791 | 0.92 | HRH3 (0.37) | HRH3HPGDBTKMAPK1EPHX1 | |
| SCHEMBL25277997 | 0.88 | HRH3 (0.37) | HRH3HPGDBTKMAPK1EPHX1 | |
| SCHEMBL30525657 | 0.84 | HRH3 (0.39) | HRH3HPGDBTKMEN1KMT2A | |
| SCHEMBL2223446 | 0.83 | HRH3 (0.41) | HRH3HPGDBTKGRM5MEN1 | |
| SCHEMBL17765394 | 0.82 | MAPK1 (0.37) | HRH3HPGDBTKMEN1KMT2A | |
| SCHEMBL30718246 | 0.81 | HRH3 (0.36) | HRH3HPGDBTKMAPK1EPHX1 | |
| SCHEMBL3403265 | 0.81 | SMN1; SMN2 (0.45) | GRM5ALDH1A1MAPTHSD11B1 | |
| SCHEMBL2633813 | 0.81 | HRH3 (0.42) | HRH3HPGDBTKGRM5MEN1 | |
| SCHEMBL21669632 | 0.80 | CYP2C19 (0.41) | HRH3BTKGRM5KMT2AMAPK1 | |
| SCHEMBL9977777 | 0.79 | SMN1; SMN2 (0.42) | GRM5ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966210-A2 | SULPHONAMIDOANILINE DERIVATIVES BEING JANUS KINASES INHIBITORS | Novartis AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071393-A2 | SULPHONAMIDOANILINE DERIVATIVES BEING JANUS KINASES INHIBITORS | NOVARTIS AG (CH) | 2007-06-28 | — | — | WO | disclosed |