Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648763 | 0.87 | GAA (0.53) | HSD17B10GAAKDM4EALDH1A1TP53 | |
| SCHEMBL4646681 | 0.80 | GAA (0.51) | HSD17B10GAAALDH1A1KIF11 | |
| SCHEMBL4648742 | 0.79 | USP2 (0.52) | USP2HSD17B10GAAKDM4EALDH1A1 | |
| SCHEMBL4648748 | 0.77 | USP2 (0.43) | USP2HSD17B10GAAKDM4EALDH1A1 | |
| SCHEMBL19732961 | 0.74 | USP2 (0.58) | USP2HSD17B10GAAKDM4EALDH1A1 | |
| SCHEMBL10279779 | 0.74 | USP2 (0.58) | USP2HSD17B10GAAKDM4EALDH1A1 | |
| SCHEMBL19732923 | 0.74 | USP2 (0.79) | USP2HSD17B10KDM4EALDH1A1TP53 | |
| SCHEMBL13789190 | 0.74 | USP2 (0.79) | USP2HSD17B10KDM4EALDH1A1TP53 | |
| SCHEMBL19732955 | 0.74 | USP2 (0.79) | USP2HSD17B10KDM4EALDH1A1TP53 | |
| SCHEMBL2569532 | 0.73 | USP2 (0.52) | USP2HSD17B10GAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675834-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1675834-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005037799-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-04-28 | — | — | WO | claimed |