Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778958 | 0.90 | MAPT (0.44) | MAPTMAPK1HTTSMN1; SMN2HRH2 | |
| SCHEMBL1779662 | 0.88 | MAPT (0.45) | MAPTMAPK1HTTSMN1; SMN2HRH2 | |
| SCHEMBL1779447 | 0.86 | MAPT (0.54) | MAPTMAPK1HTTSMN1; SMN2RAB9A | |
| SCHEMBL1777754 | 0.86 | MAPT (0.54) | MAPTMAPK1HTTSMN1; SMN2RAB9A | |
| SCHEMBL1778609 | 0.86 | MAPT (0.47) | MAPTMAPK1HTTSMN1; SMN2HRH2 | |
| SCHEMBL1778317 | 0.86 | CNR1 (0.47) | MAPTMAPK1HTTSMN1; SMN2HRH2 | |
| SCHEMBL1780444 | 0.86 | HRH2 (0.42) | MAPTMAPK1HTTSMN1; SMN2HRH2 | |
| SCHEMBL1779350 | 0.85 | MAPT (0.46) | MAPTMAPK1HTTSMN1; SMN2HRH2 | |
| SCHEMBL1778500 | 0.85 | MAPT (0.46) | MAPTMAPK1HTTSMN1; SMN2RAB9A | |
| SCHEMBL12603493 | 0.83 | MAPT (0.50) | MAPTMAPK1HTTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966187-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071952-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |